Nowadays, a methanolwater solution containing about 40% of the. The side effects of microcrystalline cellulose synonym. Microcrystalline cellulose is a commonly used excipient in the. Microcrystalline cellulose is considered an inert dust, which is not toxic to the lung when exposures are properly contr are known. The unusual properties of microcrystalline cellulose as a potential stabiliser and fat mimetic were first studied by dr battista at the american viscose corporation in 1957 alexander, 1979.
Microcrystalline cellulose is negative in the ames mutagenicity assay, and caused no chromosome damage in the mouse micronucleus assay. Carboxymethyl cellulose msds pdf aqualon cmc 7l sodium carboxymethylcellulose. Pdf microcrystalline cellulose, a direct compression. With a wide range of chemical, technical, and economic benefits, mcc is one of the most widely used binder excipients for tablet formulations. Its versatility in direct compression extends to very high dose actives, where compactability is at a premium. Microcrystalline cellulose is also used to prevent thickening in many food products due to its texture and chemical makeup. Microcrystalline cellulose mcc i s pure partially depolymerized cellulose synthesized from. The microcrystalline cellulose is an important ingredient in pharmaceutical, food, cosmetic and other industries.
Ribbons do not stick to the compaction rolls during roller compaction and dry granulation can be used in formulations with a high drug dosage. Classification according to regulation ec no 12722008. Degree of polymerization, identification c nmt 350 units. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates.
Below is the msds for our cellulose acetate membrane membranes. Microcrystalline cellulose is basically cellulose and can only be derived from a specialized grade of alpha cellulose from fibrous. Common name microcrystalline cellulose formula c 6 h 10 o 5n cas number 9004346 section 4. For dry granulation pharmacel 101 opens up vital production synergies. Microcrystalline cellulose an overview sciencedirect. Jul 17, 2015 microcrystalline cellulose e460 is used as a texturizer, an anticaking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Carcinogenic categories iarc international agency for research on cancer.
Sigmaaldrich offers a number of microcrystalline cellulose products. Material safety data sheet avicel ph microcrystalline cellulose msds ref. Nonwood fibre production of microcrystalline cellulose from. Material safety data sheet cellulose curran cellucomp. Technoeconomic analysis of simplified microcrystalline. Cellulose powder material safety data sheet sdsmsds. Prepare iodinated zinc chloride solution by dissolving 20 g of zinc chloride and 6. An adi not specified was established at the 49th jecfa 1998. This product has been classified in accordance with the hazard criteria of the cpr and the msds contains all of the information required by the cpr. Micro crystalline cellulose material safety data sheet this document has been prepared to meet the requirements of the u. Material safety data sheet carboxymethyl cellulose, sodium salt, average mw 90. Material safety data sheet nitrocellulose membrane filter. Safety data sheet in accordance with regulation eu no 4532010 109123 microcrystalline cellulose 112 ph.
The objective of this work was to find a rapid, highyield process to obtain an aqueous stable colloid suspension of cellulose nanocrystalswhiskers. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in. Material safety data sheet microcrystalline cellulose mcc msds 1. If breathing is irregular or stops, perform artificial respiration. We operate in more than 30 countries and deliver an extensive portfolio of mission critical products, services and solutions. The amalgamation of polymer and pharmaceutical sciences led to the introduction of polymer in the design and development of drug delivery systems. A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Safety data sheet northwest missouri state university. Trademark cpr and the msds contains all the information required by the cpr. Find msds or sds, a coa, data sheets and more information. However, the data is provided without any warranty, expressed or implied, regarding its correctness or. Avantor is a trusted global partner to customers and suppliers in the life science, advanced technology and applied materials industries. Not more than 10% of the particles have a diameter below 5. The new usp microcrystalline cellullose monograph pdf.
It was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed t o humid conditions, but the effect is reversed upon the removal of increased humidities. Microcel microcrystalline cellulose mcc recommended use of the chemical. Microcrystalline cellulose mcc market size statistics 2026. Safety data sheet according to 29cfr19101200 and ghs rev. The information in this microcrystalline cellulose e460 msds was obtained from current and reliable sources. Pharmacel 101 microcrystalline cellulose mcc is also an ideal excipient for use in dry granulated formulations. Certificate of analysis coa specification sheet pdf raman ftir pdf similar products. The hazards presented for pulp, cellulose, pertain to dustparticulate. Microcrystalline cellulose mcc is a term for refined wood pulp and is used as a texturizer, an anticaking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Technoeconomic analysis of simplified microcrystalline cellulose process kari m. Articles of cellulose microcrystalline are included as well. Microcrystalline cellulose side effects, side effects of. Portions of this monograph that are national usp text, and are not part of the harmonized text, are marked with symbols to specify this fact.
In this study, the microcrystalline cellulose, obtained from the stalk of sorghum caudatum was evaluated for its physical and tableting characteristics. Microcrystalline cellulose in tableting pdf free download. Methods and material for containment and cleaning up. Show this safety data sheet to the doctor in attendance. The mcc can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion and acid hydrolysis. Fire fighting measures suitable extinguish media water, foam and. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The most common form is used in vitamin supplements or tablets. Cellulose microcrystalline cas 9004346 msds guidechem.
As a boundless renewable resource, cellulose has a potential on producing environmental friendly and biocompatible products. Magnesium stearate compared with conventional microcrystalline cellulose. Pdf optimization of the isolation of nanocrystals from. Microcrystalline cellulose avicel, fmc corporation is prepared by acid hydrolysis of cellulose using 2 m hydrochloric acid at 105 c for 15 min. Microcrystalline cellulose, nf 9004346 c1679 spectrum. Microcrystalline cellulose market size was usd 868. Microcrystalline cellulose mcc, a type of cellulose that has undergone purification and partial hydrolyzation, is widely used in several industries including food production, beverage. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practice. All spectrum chemical nf grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Large quantities are required since these whiskers are designed to be extruded into polymers in the. Safety data sheet 109122 microcrystalline cellulose 102. Cellulose microcrystalline msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Msds hydroxypropyl methylcellulose, ohs11284, cas 9004653 mdl data bank, revision date december 9, 1997. Silicified microcrystalline cellulose pdf silicified microcrystalline cellulose smcc is a novel tableting excipient which.
Microcrystalline cellulose prepared at the 55th jecfa 2000 and published in fnp52 add 8 2000, superseding specifications prepared at the 51st jecfa 1998 and published in fnp 52 add 6 1998. The powdered grades, first marketed in 1961, were originally used as sources of fibre in lowcalorie foods but later found wide acceptance within the. Microcrystalline cellulose has many uses but its main use is as an excipient in the pharmaceutical industry as a binder in tablet formation. Cellulose microcrystalline, powder cotton linters sigma. If inhaled if breathed in, move person into fresh air. The later process can be done using mineral acids such as h2so4, hcl and hbr as well as ionic liquids. Cellulose microcrystalline revision date 29jun2018 sara 3112 hazard categoriessee section 2 for more information cwa clean water act not applicable clean air act not applicable osha occupational safety and health administration not applicable cercla not applicable california proposition 65 this product does not contain any proposition 65 chemicals. Proprietary ingredients indicated as hazardous have been assessed under standards for workplace. The degree of polymerization is typically less than 400. Naturally, cellulose resembles in micro fibrils form and composes of. In this study, the effect of powder cellulose pc and 2 types of microcrystalline cellulose mcc 101 and mcc 301 on pellet properties produced by an extrusionspheronization process was investigated.
In case of skin contact wash off with soap and plenty. Cellulose microcrystalline for thin layer chromatography. As early as 1969, safanova and klenkova had described the heterogeneous benzoylation of microcrystalline cellulose. Microcrystalline cellulose 9004346 1540 amoxicillin trihydrate 636707 1555 potassium clavulanate clavulanic 61177455 acid 420 dosedependent in accordance with 29 cfr 1910.
Microcrystalline cellulose is fully biodegradable and its products of degradation are more toxic. In case of skin contact wash off with soap and plenty of water. The results of xrd and raman analysis combined with curvefitting method show that the content of ordered carbon microcrystalline structure in beta3p is higher than the contents of other two samples, and beta2p has the lowest content of this microcrystalline structure. Material safety data sheet hydroxypropyl methylcellulose. Microcrystalline cellulose may create an allergic reaction in some patients, although there are few reported cases of this. Microcrystalline cellulose, nf is an excipient in pharmaceutical formulations acting as a binder in tablet formation. Damp cellulose can be a significant fire hazard since it may undergo spontaneous combustion. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater.
Microcrystalline cellulose msds, microcrystalline cellulose. Dahl this work presents a technoeconomic analysis of two modelled microcrystalline cellulose mcc production facilities, a standalone mill. Microcrystalline cellulose 9004346 2326749 not listed dicalcium phosphate 7757939 2318261 not listed sodium starch glycolate 9063381 not listed not listed magnesium stearate 557040 2091503 not listed additional information. Cellulose powder cas no 9004346 material safety data. Get medical attention for any breathing difficulty. Microcrystalline cellulose has no taste or flavor, so supplements that contain microcrystalline cellulose are easily taken. Properties of microcrystalline cellulose and powder cellulose. The different investigated types of cellulose displayed different behavior during the extrusionspheronization process. Photographs of microcrystalline cellulose sample separated from cotton waste ii sort lint at the same time, also the microcrystalline structure of mcc is well visible. Microcrystalline cellulose is often used in whey protein powders and drinks containing whey. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith. Extraction and characterization of microcrystalline cellulose.
Safety data sheet molecular weight 160 000 560 000 chemical name cas number % by weight cellulose 9004346 100 composition there are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as health hazards and hence require reporting in this section. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Cellulose, a glucan polymer that made up from dglucopyranose units and joined together by. Microcrystalline cellulose microcrystalline cellulose mcc is an odorless, tasteless, porous white powder derived from pharmaceutical grade wood pulp. We make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. The new usp microcrystalline cellullose monograph pdf download available united states pharmacopoeia the revision to the harmonized standard for microcrystalline cellullose has been approved by the pharmacopeial discussion group pdg as described in its pdg signoff cover sheet. You can download a pdf formatted copy in adobe acrobat26. Cellulose microcrystalline for thinlayer chromatography. Cellulose microcrystalline cas 9004346 msds download.
Material safety data sheet carboxymethyl cellulose, sodium. The later process can be done using mineral acids such as h. The microcrystalline cellulose monograph will be incorporated into and become official with the second supplement to the usp 42nf 37. Preparation this msds has been prepared to meet the requirements of the brazilian regulatory standard 147254. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Microcrystalline cellulose an overview sciencedirect topics. Avicel rccl microcrystalline cellulose and sodiumcarboxymethylcellulose safety data sheet download 595756 msds ghsclp.
Safety data sheet 109122 microcrystalline cellulose 102 ph. Microcrystalline cellulose mcc is pure partially depolymerized cellulose synthesized from. Though its considered safe, some are convinced it has potentially dangerous health effects. Shangraw t h e development of microcrystalline cellulose has made available t o the pharmaceutical industry an extremely valuable tableting agent.
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